I never thought a 20 minute run could take that much out of me. I hadn't run in five weeks, save one, plus I was probably stoned out of my mind when I did it. Vikadin lasts 4-6 hours, and I went out for a spin just after 4. I was a little out of breath to be honest, but I have been sitting on the couch for the last four days. The speed was there, but I had zero endurance, that will come though. Other than that, no major issues; I never even thought about my ankle, and it didnt give me any trouble. I'll run the rest of the week time, not distance, so I can work on that endurance.